The Fuller Research Foundation is a 501(c)(3) nonprofit organization committed to rigorously advancing scientific knowledge of dietary and alternative interventions for the management of chronic diseases. The Foundation supports high-quality, ethically conducted research, primarily through funding and collaboration, to evaluate the safety, efficacy, and mechanisms of approaches such as strict ruminant-meat-based ketogenic elimination protocols, broader ketogenic diets, and related evidence-informed nutritional strategies.
We aim to empower individuals with effective, sustainable solutions for improving their health and well-being. Through collaboration with researchers, healthcare providers, and communities, we strive to illuminate pathways to better health, foster informed decision-making, and inspire hope for those facing chronic conditions.
Founder and vision
The Fuller Research Foundation was established by Mikhaila Fuller, whose path to founding it was anything but straightforward. Over 21 years, she experienced severe autoimmune disease and treatment-resistant mood disorders before discovering the profound therapeutic potential of ketogenic and carnivore dietary protocols. What followed was not simply recovery, it was a decade of navigating the aftermath of long-term pharmaceutical treatment, including the well-documented but rarely discussed harms of long-term SSRI use and withdrawal.
That experience shaped a broader mission: not only to fund rigorous research into dietary and lifestyle interventions for chronic disease, but to build an honest, evidence-based understanding of the full picture, the environmental causes that drive illness, the dietary and lifestyle approaches that can reverse it, and the pharmaceutical harms that so often remain long after the original diagnosis has been addressed. The Foundation’s research agenda and public education work reflect all three of these dimensions.
The evidence landscape
Much of the current evidence in autoimmunity stems from animal models, where ketogenic diets have demonstrated reductions in inflammation, modulation of immune responses (such as shifting toward anti-inflammatory Treg cells), and symptom amelioration, often linked to ketone bodies like β-hydroxybutyrate.
In humans, small-scale pilot studies have explored ketogenic diets primarily in multiple sclerosis, reporting improvements in fatigue, depression, quality of life, and inflammatory markers with good safety and tolerability over periods like 6 months.
Large-scale, definitive randomized controlled trials across broader autoimmune diseases, lupus, Crohn’s disease, IBD, or general autoimmunity, are scarce. High-quality, large-scale human trials are needed to establish efficacy, long-term safety, and mechanisms.
Our commitment
The Fuller Research Foundation is dedicated to conducting and supporting research that is transparent, methodologically sound, and participant-centered. By partnering with qualified investigators, academic institutions, and healthcare professionals, the Foundation seeks to generate reliable evidence on the role of targeted dietary interventions in chronic disease management, contributing meaningfully to the broader scientific community’s understanding and supporting informed clinical decision-making.
